Neurobiology of Disease Combined Effects of Alzheimer Risk Variants in the CLU and ApoE Genes on Ventricular Expansion Patterns in the Elderly
نویسندگان
چکیده
Florence F. Roussotte,1,3 Boris A. Gutman,3,4 Sarah K. Madsen,3,4 John B. Colby,1 and Paul M. Thompson1,2,3,4,5 for the Alzheimer’s Disease Neuroimaging Initiative* 1Department of Neurology, and 2Department of Psychiatry, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, 3Imaging Genetics Center, and 4Departments of Neurology, and 5Psychiatry, Radiology, Engineering, Pediatrics, and Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033
منابع مشابه
Apolipoprotein E epsilon 4 allele is associated with ventricular expansion rate and surface morphology in dementia and normal aging.
The apolipoprotein E epsilon 4 allele (ApoE-ε4) is the strongest known genetic risk factor for late onset Alzheimer's disease. Expansion of the lateral ventricles occurs with normal aging, but dementia accelerates this process. Brain structure and function depend on ApoE genotype not just for Alzheimer's disease patients but also in healthy elderly individuals, and even in asymptomatic young in...
متن کاملGenotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.
OBJECTIVE Several genome-wide association studies (GWAS) have associated variants in late-onset Alzheimer disease (LOAD) susceptibility genes; however, these single nucleotide polymorphisms (SNPs) have very modest effects, suggesting that single SNP approaches may be inadequate to identify genetic risks. An alternative approach is the use of multilocus genotype patterns (MLGPs) that combine SNP...
متن کاملMeta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
OBJECTIVES To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes. DESIGN Association study of AD and CLU, PICALM, CR1, and APOE genotypes. SETTING Academic research institutions in the United States, Canada, and Israel. PARTICIPANTS Seven thousand ...
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Objectives GSTs are detoxification enzymes that remove excess reactive oxygen species (ROS) from cells. Evidence suggests that oxidative stress plays a role in several stages of the neurodegenarative disease like Alzheimer disease. Free radicals and similar molecules are classified as reactive oxygen species (ROS), which can cause oxidative modifications in the cell. In this study we have inves...
متن کاملTwo Lung Cancer Development-Related Genes, Forkhead Box M1 (FOXM1) and Apolipoprotein E (APOE), are overexpressed in Bronchial of Patients after Long-Term Exposure to Sulfur Mustard
Sulfur mustard (SM) is a strong alkylating and mutagenic compound that targets humanairway system. We considered the expression of Forkhead box M1 (FOXM1) and apolipoproteinE (APOE) genes, which are responsible for cell proliferation, differentiation, tumorigenesis,and increased risk of lung cancer, in the lung bronchial tissue of patients exposed to SM.After performing pulmonary functional tes...
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تاریخ انتشار 2014